Given that both cognitive behavioural therapy (CBT) and the use of selective serotonin reuptake inhibitors have independently been shown to be effective in treating problem gambling, the present study will look at the effects of these treatments alone and in combination in reducing gambling behaviours, as well as in changing motivational, attitudinal, and cognitive indices associated with the disorder. Thirty-four problem gambling participants were randomly assigned to one of three treatment groups: (1) Medication (paroxetine [Paxil®]) alone; (2) CBT plus medication (Paxil®); or (3) CBT plus placebo. While symptom levels declined among all groups, individuals who received treatment with both CBT and Paxil® demonstrated the most rapid decrease in gambling-related symptoms when compared to those who received only Paxil® or CBT and a placebo, as measured by the self-rating Gambling Symptom Assessment Scale.