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News:
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Neurochemistry related to abilities to inhibit response and not be distracted by irrelevant information in gambling disorder

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View Abstract View Snapshot Back to Search Results

snapshot summaries


Author(s): Weidacker, Kathrin ; Johnston, Stephen J. ; Mullins, Paul G. ; Boy, Frederic ; Dymond, Simon

Journal: CNS Spectrums

Year Published: 2021

Date Added: July 10, 2021

People who have a problematic relationship with gambling have gambling disorder (GD). Research suggests that people with GD have difficulties in regulating their actions. This study aimed to assess how people with GD performed on behavioural tasks. These behavioural tasks measured their response inhibition and their resistance to distractor interference. The researchers also used a brain scanning technique to see if performance on these tasks was related to neurochemical levels in specific regions of the brain. This study found that people with GD were slower during the distractor interference task. Neurochemical levels in the dorsal anterior cingulate cortex area of the brain seemed to be involved in their resistance to distractor interference.


Citation: Weidacker, K., Johnston, S. J., Mullins, P. G., Boy, F., & Dymond, S. (2021). Neurochemistry of response inhibition and interference in gambling disorder: A preliminary study of γ-aminobutyric acid (GABA+) and glutamate-glutamine (Glx). CNS Spectrums, 1-11. https://doi.org/10.1017/S1092852921000316

Article DOI: https://doi.org/10.1017/S1092852921000316

Keywords: behaviour ; gambling disorder ; neurobiology ; response inhibition ; Stop Signal Task (SST)

Topics: Biological Factors ; Gambling and the Brain

Conceptual Framework Factors:   Psychological Factors ; Biological Factors ; Biological - Neurobiology

Study Design: Observational: Case Control

Geographic Coverage: United Kingdom, Wales

Study Population: 26 adult males; 12 disordered gamblers and 14 age-matched males who did not have gambling disorder

Study Funding:

This study was funded by the International Center for Responsible Gambling and the Department of Psychology at Swansea University

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    • Funding Opportunities
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    • Data Repository
    • Evidence Centre
    • Gambling from a Public Health Perspective
    • Prevention and Education Review: Gambling-Related Harm
    • Research to Inform Action Evidence Hub
    • Safer Gambling Evaluation Evidence Hub
    • Resources for Safer Gambling During COVID-19
  • Partners
    • National Strategy to Reduce Gambling Harms in Great Britain
    • Academic Forum for the Study of Gambling (AFSG)
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