This study examined the link between gambling disorder (GD) and work disability. It also mapped the trajectories of work disability three years before and three years after GD diagnosis. People with GD showed an increased risk for long-term work disability than people without GD. Four different trajectories of work disability were identified among people with GD. Females, older people, people with a previous psychiatric diagnosis, and those who received psychotropic medication were less likely to be in the group with low constant levels of work disability.