This article provides an overview of how gambling-related harms (GRHs) have been measured over the last 20 years. The authors discuss how the measurement of GRHs has evolved, from repurposing existing measures of problem gambling severity to developing dedicated measures of GRHs. The authors argue that it is important to consider and quantify how GRHs lower a person’s health-related quality of life (HRQoL). They suggest a hybrid approach for grounding GRHs to HRQoL. Linking GRH scores to declines in HRQoL is challenging, but important to compare gambling with other health conditions. This review provides directions for future research, which is needed to inform evidence-based policy.