A review and comparison of pharmacological treatments for gambling disorder

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Author(s): Ioannidis, Konstantinos ; Del Giovane, Cinzia ; Tzagarakis, Charidimos ; Solly, Jeremy E. ; Westwood, Samuel J. ; Parlatini, Valeria ; Bowden-Jones, Henrietta ; Grant, Jon E. ; Cortese, Samuele ; Chamberlain, Samuel R.

Journal: Comprehensive Psychiatry

Year Published: 2025

Date Added: March 14, 2025

Currently, there is no consensus about the most effective way to treat gambling disorder. This article outlines a systematic review and a network meta-analysis (NMA) that compared the effects of pharmacological treatments on symptoms and quality of life in the management of gambling disorder. This article helps clarify which medications have the highest efficacy and are most tolerable for treating gambling disorder. The findings can inform clinical practice and guidelines for the treatment of gambling disorder.

Citation: Ioannidis, K., Del Giovane, C., Tzagarakis, C., Solly, J. E., Westwood, S. J., Parlatini. V., Bowden-Jones, H., Grant, J. E., Cortese, S., & Chamberlain, S. R. (2025). Pharmacological management of gambling disorder: A systematic review and network meta-analysis. Comprehensive Psychiatry, 137, 152566. https://doi.org/10.1016/j.comppsych.2024.152566

Article DOI: https://doi.org/10.1016/j.comppsych.2024.152566

Keywords: gambling disorder ; interventions ; pharmacology ; quality of life

Topics: Gambling Resources ; Information for Operators ; Information for Treatment Providers

Conceptual Framework Factors: Biological Factors ; Gambling Resources ; Resources - Interventions

Study Design: Systematic Review

Study Funding:

This study was supported by unrestricted grant funds to Professor Chamberlain held at the University of Southampton, originating from the NHS.