Gambling, alcohol, and substance use problems harm individuals as well as their families. This article reviews research on family-focused interventions for gambling, alcohol, and substance use problems. It shows that few studies have looked at family-focused interventions for problem gambling. Additionally, few studies try to understand how to adapt interventions to people of different ages, cultures, or socioeconomic backgrounds. Overall, this review shows that involving families in interventions benefits the person with the addiction as well as their family members. However, more research is needed to address several gaps in our knowledge.