There is ongoing debate on how to assess the impact of gambling problems on health and wellbeing. Previous studies have relied on a direct elicitation approach to make the estimates. In this article, the authors discuss the direct elicitation approach and its limitations. They propose an indirect elicitation approach as an alternative way. This approach requires matching people with gambling problems to people without any gambling problems. It demands good knowledge of risk factors and co-occurring health conditions to estimate the unique impact of gambling problems on health and wellbeing. The authors summarize current knowledge regarding both risk factors and co-occurring health conditions.