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Examining antidepressant prescription as a risk factor for gambling disorder using registry data in Norway

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Author(s): Kaur, Puneet ; Smith, Otto R. F. ; Leino, Tony ; Erevik, Eilin K. ; Griffiths, Mark D. ; Goudriaan, Anna E. ; Pallesen, Ståle

Journal: Journal of Behavioral Addictions

Year Published: 2025

Date Added: May 28, 2025

This study examined the relationship between antidepressant prescriptions and the likelihood of developing gambling disorder over time. In doing so, the researchers used antidepressant prescriptions as a proxy for depression diagnosis. The researchers used data from the Norwegian Patient Registry (NPR) and the Norwegian Prescription Registry (NorPD) from 2008 to 2018. The study group included 5,131 patients who were diagnosed with gambling disorder. This group was compared to 22,289 patients with other illnesses (control group) who were matched in terms of age and gender.

A total of 1,488 patients were prescribed antidepressants before they received a gambling disorder diagnosis. Patients who were prescribed antidepressants were 2.8 times as likely to develop gambling disorder as those who were not prescribed antidepressants. Women were less likely to develop gambling disorder compared to men (odds of 0.78). For each passing year, the chance of developing gambling disorder went up by 1% for patients who were prescribed antidepressants.


Citation: Kaur, P., Smith, O. R. F., Leino, T., Erevik, E. K., Griffiths, M. D., Goudriaan, A. E., & Pallesen, S. (2025). Antidepressant prescription as a risk factor for developing gambling disorder: A longitudinal registry-based study in Norway. Journal of Behavioral Addictions, 14(1), 457–464. https://doi.org/10.1556/2006.2024.00047

Article DOI: https://doi.org/10.1556/2006.2024.00047

Keywords: antidepressants ; depression ; gambling disorder ; risk factors

Topics: Anxiety and Depression ; Comorbidities ; Cultural Factors

Conceptual Framework Factors:   Psychological - Comorbid Disorders ; Resources - Risk Assessment ; Psychological Factors ; Gambling Resources

Study Design: Observational: Case Control

Geographic Coverage: Norway

Study Population: Adults (18+ years) who received treatment through Norwegian public specialized healthcare services, including those with gambling disorder (n= 5131) and those without (n=22,2989).

Sampling Procedure: Data from the Norwegian Patient Registry (NPR) and the Norwegian Prescription Registry (NorPD) were used in this study.

Study Funding:

This study was funded by the Research Council of Norway. Open access funding was provided by the University of Bergen, Norway.

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