This fact sheet by the World Health Organization summarizes key facts about gambling and gambling harm globally. The fact sheet briefly outlines the scope of harm, who is at most risk of harm, signs and symptoms of gambling disorder, what drives transmission of gambling and harm, and prevention and treatment of harm. The World Health Organization states the need for countries to monitor and regulate gambling operations effectively. This includes actions to prevent and reduce harm such as reducing stigma and shame related to gambling, and ending advertising and promotion. Initiatives by the World Health Organization involve leading the creation of diagnostic tools for gambling disorder for people in countries outside North America and sharing some lessons learned around gambling regulation. This is important to support countries where commercial gambling activity is rapidly increasing, especially low- and middle-income countries.