‘Work life’ and ‘family life’ can conflict with each other in many ways. Recently, more scholars are looking at understanding how other nonwork areas (e.g., leisure, health, education) cause different types of interference in work and family life. This study tested a process-oriented framework to explore gambling interference in work and nonwork domains. The researchers also assessed whether cognitive withdrawal from work and nonwork roles linked gambling interference to reduced role performance. Participants (259) were recruited from Amazon’s Mechanical Turk (MTurk). To meet inclusion criteria, they had to be living in the United States, be 18 years of age or older, gambled at least weekly, and worked 20 or more hours per week. Findings suggest that gambling behaviour creates strain and interferes with both work and nonwork roles. This in turn reduces job performance and negatively impacts nonwork areas. Cognitive withdrawal from one’s role partly explains the negative effects of gambling on role performance in work and nonwork areas.