Neurotrophin genes may be involved in gambling disorder

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Author(s): Solé-Morata, Neus ; Baenas, Isabel ; Etxandi, Mikel ; Granero, Roser ; Forcales, Sonia V. ; Gené, Manel ; Barrot, Carme ; Gómez-Peña, Mónica ; Menchón, José M. ; Ramoz, Nicolás ; Gorwood, Philip ; Fernández-Aranda, Fernando ; Jiménez-Murcia, Susana

Journal: Scientific Reports

Year Published: 2022

Date Added: September 27, 2022

Some people develop a problematic relationship with gambling. This can lead to gambling disorder (GD). The researchers of this study wanted to better understand the genetics involved in GD. A total of 166 people with GD and 191 people without GD (the control group) participated in a genotyping study, where their unique genetic code was profiled. The researchers found four single nucleotide polymorphisms (SNPs) for neurotrophin genes that distinguished the GD group from the control group. They also found that two haplotypes, which are groups of SNPs, distinguished the two groups. One haplotype increased the risk of GD and the other decreased the risk of GD. Finally, the location of the SNPs in genetic code could have important information related to how the SNPs functionally contribute to the development of GD.

Citation: Solé-Morata, N., Baenas, I., Etxandi, M., Granero, R., Forcales, S. V., Gené, M., Barrot, C., Gómez-Peña, M., Menchón, J. M., Ramoz, N., Gorwood, P., Fernández-Aranda, F., & Jiménez-Murcia, S. (2022). The role of neurotrophin genes involved in the vulnerability to gambling disorder. Scientific Reports, 12, Article 6925. https://doi.org/10.1038/s41598-022-10391-w

Article DOI: https://doi.org/10.1038/s41598-022-10391-w

Keywords: biological factors ; gambling disorder ; genetics ; vulnerability ; vulnerability marker

Topics: Biological Factors

Conceptual Framework Factors: Biological Factors ; Biological - Genetic Inheritance

Study Design: Observational: Case Control

Geographic Coverage: Spain

Study Population: 166 people admitted to the Outpatient Gambling Disorder Unit at the University Hospital of Bellvitge who were diagnosed with gambling disorder according to DSM-IV, and 190 people in the control group (inclusion criteria not described)

Sampling Procedure: Targeted sampling (participants admitted to hospital were recruited consecutively) and voluntary response sampling (control group was recruited from advertisements)

Study Funding:

This study was funded by CERCA Programme/ Generalitat de Catalunya, as well as grants from the Ministerio de Ciencia, Innovación y Universidades, the Delegación del Gobierno para el Plan Nacional sobre Drogas, and Instituto de Salud Carlos III. It was also co-funded by FEDER funds/European Regional Development Fund. Additional support came from EU Grant Eat2beNice, PRIME, and COST Action.