This study examined the predictors and effects of message fatigue towards responsible gambling (RG) messages. Users of Amazon Mechanical Turk who were at least 21 years old and from the United States were recruited to complete an online survey. The final sample consisted of 822 participants. Respondents who had more severe gambling problems or gambled more often were more likely to feel fatigued by RG messages. Respondents who worked in the gambling industry were less likely to report feeling fatigued by RG messages. Feeling fatigued by RG messages was linked to higher levels of reactance and inattention. In turn, higher levels of reactance and inattention were linked to greater gambling intentions. Finally, higher levels of reactance and intention were also linked to lower intentions to share RG messages with others.